What side effects do tocotrienols have? Tocotrienols are a vitamin that occurs naturally in every cell and is well managed in the body
But there is a side effect, namely Blood thinning (anti-coagulation). In general, vitamin E significantly reduces the blood's tendency to clot. Namely by 75% in a dosage of 200 IU after two weeks, as a 1989 study found(82% in 400 IU).
Actually, this would be a desirable effect, as many thousands of people take medication to inhibit coagulation every day.
However, the blood thinning can also be too severe. This can occur if medication for blood thinning and the tocotrienols are already taken. So if you are taking blood thinning medications (such as "Marcumar" or the NEAK), the cardiologist should redetermine the INR and readjust the medication after you take the tocotrienols.
Excessive blood thinning caused by tocotrienol alla has not yet been reported.
During operations (surgical interventions), the attending physician must be informed about blood-thinning medications, as this prolongs the bleeding time. This should also be done while taking vitamin E, including tocotrienol, and these should be stopped a few days before the operation. Tocotrienols have a short half-life in the body (3-6 days), so traces of tocotrienol would no longer be detectable after just 1-2 days. However, this does not apply to conventional tocopherol, which is stored in the body for months.
Another consideration: There are restrictions on conventional vitamin E (alpha-tocopherol) after an increased risk was found in doses above 268 mg (300 IU) in two metastatic cases. But this only applies to alpha-tocopherol and alpha-tocotrienol. The great thing is that the alpha-tocopherol itself becomes the weaker radical. The other isomers (beta, delta and gamma) have no quantity limits. This also results automatically from the conversion into the official unit “mg alpha-tocopherol equivalents”. In these cases, the higher isomers (beta-, delta- and gamma-tocotrienol) do not work at all.